<var id="zzpbr"></var>

<em id="zzpbr"></em>
<em id="zzpbr"><i id="zzpbr"></i></em>
<optgroup id="zzpbr"></optgroup>
    <strike id="zzpbr"></strike>

    <optgroup id="zzpbr"><mark id="zzpbr"><delect id="zzpbr"></delect></mark></optgroup>
    <nobr id="zzpbr"><menuitem id="zzpbr"><progress id="zzpbr"></progress></menuitem></nobr>

    <optgroup id="zzpbr"><menuitem id="zzpbr"><delect id="zzpbr"></delect></menuitem></optgroup>

          Novel algorithms for efficient subsequence searching and mapping in nanopore raw signals towards targeted sequencing

          Speaker:   Dr. Sheng Wang

          Time:       16:30-17:30, Sep. 2

          Location:  SIST 1A 212

          Host:       Prof. Jie Zheng

           

          Abstract:

          Genome diagnostics have gradually become a prevailing routine for human healthcare. With the advances in understanding the causal genes for many human diseases, targeted sequencing provides a rapid, cost-efficient and focused option for clinical applications, such as SNP detection and haplotype classification, in a specific genomic region. Although nanopore sequencing offers a perfect tool for targeted sequencing because of its mobility, PCR-freeness, and long read properties, it poses a challenging computational problem of how to efficiently and accurately search and map genomic subsequences of interest in a pool of nanopore reads (or raw signals). Due to its relatively low sequencing accuracy, there is currently no reliable solution to this problem, especially at low sequencing coverage.

           

          Here, we propose a brand new signal-based subsequence inquiry pipeline as well as two novel algorithms to tackle this problem. The proposed algorithms follow the principle of subsequence dynamic time warping and directly operate on the electrical current signals, without loss of information in base-calling. Therefore, the proposed algorithms can serve as a tool for sequence inquiry in targeted sequencing. Two novel criteria are offered for the consequent signal quality analysis and data classification. Comprehensive experiments on real-world nanopore datasets show the efficiency and effectiveness of the proposed algorithms. We further demonstrate the potential applications of the proposed algorithms in two typical tasks in nanopore-based targeted sequencing: SNP detection under low sequencing coverage, and haplotype classification under low sequencing accuracy.

          Bio:

          Dr. Sheng Wang is a Research Scientist at King Abdullah University of Science and Technology (KAUST). He got his bachelor degree in biochemistry from Shanghai Jiaotong University (SJTU) in 2005; PhD diploma in bioinformatics from University of Chinese Academy of Sciences (UCAS) in 2010. Then he went over to Toyota Technological Institute at Chicago (TTIC) and University of Chicago to work with Prof. Jinbo Xu as a Postdoc on protein structure prediction. His current research mainly focuses on the algorithm design and the data analysis of nanopore-based third-generation sequencing. 

           

          Dr. Wang has published 17 conference articles in the fields of computational biology, including top conferences such as ISMB, RECOMB, ECCB, etc. He also published 46 articles in well-known journals, including 1 PNAS, 1 Nature Protocols, 1 Cell Systems, 6 Nucleic Acids Research, 13 Bioinformatics, 2 PLoS Computational Biology. Three of his published papers were awarded as Highly Cited Papers by Web of Science; one of his published paper has won the 2018 PLoS Computational Biology Research Prize in the category of breakthrough and innovation. His publications have been cited over ~2000 times according to Google Scholar. More details about him and his research can be found at http://ttic.uchicago.edu/~wangsheng/.

          SIST-Seminar 18196


          pc蛋蛋加拿大28官网 http://www.douban.com/search?q=秒速赛车外挂a9840。com 复制登录 http://so.iqiyi.com/so/q_pk10定位图软件a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=55彩票正规吗a9840。com 复制登录 http://www.youdao.com/w/彩票之神a9840。com 复制登录 http://so.iqiyi.com/so/q_千禧幸运飞艇开奖记录a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=8828彩票是什么a9840。com 复制登录 http://www.youdao.com/w/幸运飞艇启动图a9840。com 复制登录 http://so.iqiyi.com/so/q_福利彩票开奖结果18016a9840。com 复制登录 http://so.iqiyi.com/pps/?k=彩票主任控号a9840。com 复制登录 http://www.douban.com/search?q=太子彩票正规合法a9840。com 复制登录 http://cn.engadget.com/tag/幸运农场6中428c63。com 复制登录 http://so.iqiyi.com/pps/?k=头奖彩票appa9840。com 复制登录 http://www.xiachufang.com/search/?keyword=体育彩票6 1开奖号码a9840。com 复制登录 http://www.youdao.com/w/幸运农场买3中2有奖不a9840。com 复制登录 http://so.iqiyi.com/so/q_乐都彩票官网a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=重庆福彩幸运农场a9840。com 复制登录 http://www.douban.com/search?q=5oo彩票网国际版a9840。com 复制登录 http://cn.engadget.com/tag/703彩票网开户28c63。com 复制登录 http://so.iqiyi.com/pps/?k=广东快乐十分钟官方网a9840。com 复制登录 http://www.douban.com/search?q=美国1997年彩票号码a9840。com 复制登录 http://www.youdao.com/w/北京pk10自己坐庄a9840。com 复制登录 http://so.iqiyi.com/so/q_幸运农场我要进前十a9840。com 复制登录 http://so.iqiyi.com/pps/?k=北京pk10开奖视频直播a9840。com 复制登录 http://www.douban.com/search?q=pk10开奖直播北京赛车a9840。com 复制登录 http://so.iqiyi.com/so/q_腾讯分分彩趋势软件a9840。com 复制登录 http://so.iqiyi.com/pps/?k=北京赛车pk10开户a9840。com 复制登录 http://www.douban.com/search?q=乐天彩票不能提款a9840。com 复制登录 http://cn.engadget.com/tag/全天秒速赛车计划28c63。com 复制登录 http://so.iqiyi.com/pps/?k=在哪里有幸运飞艇买a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=大运彩票手机官网a9840。com 复制登录 http://www.youdao.com/w/广东快乐十分乐和彩a9840。com 复制登录 http://so.iqiyi.com/so/q_头奖彩票公司名称a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=免费幸运飞艇技巧a9840。com 复制登录 http://www.douban.com/search?q=淘金1彩票a9840。com 复制登录 http://cn.engadget.com/tag/九州彩票网址是什么28c63。com 复制登录 http://so.iqiyi.com/pps/?k=幸运飞艇预测软件下载a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=怎么用移动积分换彩票a9840。com 复制登录 http://www.youdao.com/w/有幸运农场的appa9840。com 复制登录 http://cn.engadget.com/tag/北京pk10免费软件28c63。com 复制登录 http://so.iqiyi.com/pps/?k=500wan彩票a9840。com 复制登录 http://www.douban.com/search?q=青海福利彩票3da9840。com 复制登录 http://cn.engadget.com/tag/幸运农场胆拖玩法28c63。com 复制登录 http://so.iqiyi.com/pps/?k=怎样在直播平台买彩票a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=金祥彩票是官方网站吗a9840。com 复制登录 http://www.youdao.com/w/幸运飞艇有没有人玩a9840。com 复制登录 http://so.iqiyi.com/so/q_中国彩票怎么下载a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=幸运飞艇8码技巧a9840。com 复制登录 http://www.douban.com/search?q=凤凰平台买彩票靠谱吗a9840。com 复制登录 http://cn.engadget.com/tag/广东快乐十分概率28c63。com 复制登录 http://so.iqiyi.com/pps/?k=幸运飞艇有开奖网站么a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=什么软件买彩票最安全a9840。com 复制登录 http://www.youdao.com/w/幸运飞艇软件怎么看直播a9840。com 复制登录 http://cn.engadget.com/tag/千金城彩票正规吗28c63。com 复制登录 http://so.iqiyi.com/pps/?k=广东快乐十分20选8玩法a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=宏光彩票网站a9840。com 复制登录 http://www.youdao.com/w/9彩彩票专业投注平台a9840。com 复制登录 http://cn.engadget.com/tag/北京pk10大富翁28c63。com 复制登录 http://so.iqiyi.com/pps/?k=腾讯的天天中彩票a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=教教我怎样买福利彩票a9840。com 复制登录 http://so.iqiyi.com/so/q_现在为啥买不了彩票了a9840。com 复制登录 http://so.iqiyi.com/pps/?k=网咯彩票a9840。com 复制登录 http://www.youdao.com/w/彩票倍率9.8什么意思a9840。com 复制登录 http://so.iqiyi.com/so/q_福利幸运飞艇a9840。com 复制登录 http://so.iqiyi.com/pps/?k=足球彩票免费领彩金a9840。com 复制登录 http://www.douban.com/search?q=移动积分换彩票a9840。com 复制登录 http://cn.engadget.com/tag/幸运飞艇pk10开奖28c63。com 复制登录 http://so.iqiyi.com/so/q_北京赛车pk10软件a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=3cp彩票APPa9840。com 复制登录 http://www.youdao.com/w/中国彩票大奖领导者a9840。com 复制登录 http://so.iqiyi.com/so/q_幸运飞艇一天开几期a9840。com 复制登录 http://so.iqiyi.com/pps/?k=体育彩票手机版5ooa9840。com 复制登录 http://www.youdao.com/w/福利彩票预测a9840。com 复制登录 http://cn.engadget.com/tag/山东体育彩票十一选五28c63。com 复制登录 http://so.iqiyi.com/pps/?k=hao500彩票网开奖视频a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=北京pk10大富翁a9840。com 复制登录 http://www.youdao.com/w/3d时时彩票开奖a9840。com 复制登录 http://so.iqiyi.com/so/q_大运彩票网是啥a9840。com 复制登录 http://so.iqiyi.com/pps/?k=哪个彩票网站高频彩多a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=北京pk10软件3码a9840。com 复制登录 http://www.youdao.com/w/重庆幸运农场快乐十分走试图a9840。com 复制登录 http://cn.engadget.com/tag/pk10十道玩法28c63。com 复制登录 http://so.iqiyi.com/pps/?k=广东快乐十分认3技巧a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=怎么用手机买淘宝彩票a9840。com 复制登录 http://www.youdao.com/w/重庆幸运农场玩法规则a9840。com 复制登录 http://cn.engadget.com/tag/百合娱乐彩票怎么样28c63。com 复制登录 http://so.iqiyi.com/pps/?k=重庆幸运农场走势a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=联运彩票平台可靠吗a9840。com 复制登录 http://www.youdao.com/w/幸运飞艇下期出号规律a9840。com 复制登录 http://cn.engadget.com/tag/彩票报纸28c63。com 复制登录 http://so.iqiyi.com/pps/?k=幸运飞艇皇家下载a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=买彩票的心情说说a9840。com 复制登录 http://www.youdao.com/w/彩票筛选软件苹果版a9840。com 复制登录 http://cn.engadget.com/tag/官方中国体育彩票下载28c63。com 复制登录 http://so.iqiyi.com/pps/?k=幸运飞艇开奖走势软件a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=3d彩票开奖近30a9840。com 复制登录 http://www.douban.com/search?q=pk10大小单双必赢a9840。com 复制登录 http://cn.engadget.com/tag/广东快乐十分计划网站28c63。com 复制登录 http://so.iqiyi.com/so/q_易算pk10注册码a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=幸运农场视频a9840。com 复制登录 http://www.douban.com/search?q=彩票500网走势图a9840。com 复制登录 http://cn.engadget.com/tag/广东快乐十分怎么玩28c63。com 复制登录 http://so.iqiyi.com/pps/?k=彩票106有好多年了a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=广东快乐十分现场a9840。com 复制登录 http://www.douban.com/search?q=pk10 玩法a9840。com 复制登录 http://cn.engadget.com/tag/重庆福彩幸运农场官方网站28c63。com 复制登录 http://so.iqiyi.com/so/q_曾夫人四不象资料a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=98彩票不能充值a9840。com 复制登录 http://www.douban.com/search?q=pk10微信号a9840。com 复制登录 http://cn.engadget.com/tag/广东快乐十分下期提前开奖软件28c63。com 复制登录 http://so.iqiyi.com/pps/?k=分分彩三星稳赚a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=微信可以买幸运农场吗a9840。com 复制登录 http://www.douban.com/search?q=怎么报复私人彩票平台a9840。com 复制登录 http://cn.engadget.com/tag/幸运农场一期计划28c63。com 复制登录 http://so.iqiyi.com/so/q_澳门永利集团娱乐官网a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=手机版幸运飞艇开奖直播a9840。com 复制登录 http://www.douban.com/search?q=北京福利彩票快3结果a9840。com 复制登录 http://cn.engadget.com/tag/重庆幸运农场胆拖技巧28c63。com 复制登录 http://so.iqiyi.com/so/q_668彩票合法吗a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=重庆幸运农场昨天开奖号码a9840。com 复制登录 http://www.douban.com/search?q=在什么网址可以买彩票a9840。com 复制登录 http://cn.engadget.com/tag/重庆幸运农场任选怎么玩28c63。com 复制登录 http://so.iqiyi.com/so/q_pk10多少期a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=彩票幸运农场秘诀a9840。com 复制登录 http://www.douban.com/search?q=北京pk10分析a9840。com 复制登录 http://cn.engadget.com/tag/时时彩总代理28c63。com 复制登录 http://so.iqiyi.com/so/q_网购彩票最新消息a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=彩票123官方网站a9840。com 复制登录 http://cn.engadget.com/tag/秒速时时彩计划软件28c63。com 复制登录 http://so.iqiyi.com/so/q_pk10彩票分析技巧a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=重庆幸运农场真的吗a9840。com 复制登录 http://www.douban.com/search?q=新疆风彩彩票35选7a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=掌上彩票是真实的吗a9840。com 复制登录 http://www.youdao.com/w/pk10幸运飞艇开奖视频a9840。com 复制登录 http://so.iqiyi.com/pps/?k=广东快乐十分开奖结果查询a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=北京pk10走势图 投注a9840。com 复制登录 http://www.youdao.com/w/滴滴彩票iosa9840。com 复制登录 http://cn.engadget.com/tag/皇家彩世界pk10开奖记录28c63。com 复制登录 http://so.iqiyi.com/pps/?k=彩票规则对冲a9840。com 复制登录 http://www.douban.com/search?q=福利彩票消消乐手机版a9840。com 复制登录 http://cn.engadget.com/tag/幸运飞艇免费预测图28c63。com 复制登录 http://so.iqiyi.com/so/q_pk10在哪买a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=秒速赛车手机软件a9840。com 复制登录 http://www.douban.com/search?q=金点北京赛车pk10a9840。com 复制登录 http://so.iqiyi.com/so/q_幸运飞艇怎样a9840。com 复制登录 http://so.iqiyi.com/pps/?k=北京赛车pk10手机a9840。com 复制登录 http://www.douban.com/search?q=怎样用淘宝买彩票a9840。com 复制登录 http://cn.engadget.com/tag/幸运飞艇走势图幸运开奖28c63。com 复制登录 http://so.iqiyi.com/so/q_pk10下注公式a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=重庆幸运农场龙虎规则a9840。com 复制登录 http://www.douban.com/search?q=聚星彩票是什么a9840。com 复制登录 http://so.iqiyi.com/so/q_莲花福利彩票的地点a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=幸运飞艇200期冷热分析a9840。com 复制登录 http://www.douban.com/search?q=彩票代购平台有哪些a9840。com 复制登录 http://cn.engadget.com/tag/好友彩票-登录页面28c63。com 复制登录 http://so.iqiyi.com/pps/?k=幸运农场走势图手机版a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=互联网彩票龙头a9840。com 复制登录 http://www.youdao.com/w/广东快乐十分官方直播a9840。com 复制登录 http://cn.engadget.com/tag/北京pk10前后八码玩法28c63。com 复制登录 http://so.iqiyi.com/pps/?k=单双大小的是什么彩票a9840。com 复制登录 http://www.douban.com/search?q=pk10龙虎是怎么区分a9840。com 复制登录 http://so.iqiyi.com/so/q_大神彩票网址a9840。com 复制登录 http://so.iqiyi.com/pps/?k=乐娱彩票登录a9840。com 复制登录 http://www.douban.com/search?q=幸运农场所有走势图a9840。com 复制登录 http://www.youdao.com/w/春节彩票不开门a9840。com 复制登录 http://so.iqiyi.com/so/q_时时彩幸运农场a9840。com 复制登录 http://so.iqiyi.com/pps/?k=极速pk10北京a9840。com 复制登录 http://www.douban.com/search?q=幸运飞艇信誉微信群a9840。com 复制登录 http://www.youdao.com/w/游戏厅彩票有什么用a9840。com 复制登录 http://so.iqiyi.com/so/q_快钱彩票合不合法a9840。com 复制登录 http://so.iqiyi.com/pps/?k=天天中彩票讨论微信群a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=北京pk10外挂a9840。com 复制登录 http://www.youdao.com/w/重庆幸运农场在线a9840。com 复制登录 http://so.iqiyi.com/so/q_北京赛车pk10彩票空a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=幸运飞艇平台doubana9840。com 复制登录 http://www.douban.com/search?q=现金平台众彩彩票网a9840。com 复制登录 http://cn.engadget.com/tag/福利彩票专家预测28c63。com 复制登录 http://so.iqiyi.com/pps/?k=爱彩彩票正规的吗a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=普通人能中彩票大奖吗?a9840。com 复制登录 http://www.youdao.com/w/幸运飞艇开奖计划图a9840。com 复制登录 http://cn.engadget.com/tag/幸运彩票528c63。com 复制登录 http://so.iqiyi.com/pps/?k=和彩彩票下载安装a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=幸运农场预测号码a9840。com 复制登录 http://www.douban.com/search?q=北京pk10计划微信群a9840。com 复制登录 http://cn.engadget.com/tag/幸运农场走试图28c63。com 复制登录 http://so.iqiyi.com/so/q_什么是彩票复制a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=幸运农场中三全中几率a9840。com 复制登录 http://www.douban.com/search?q=掌上彩票合法吗a9840。com 复制登录 http://cn.engadget.com/tag/幸运飞艇和值大小28c63。com 复制登录 http://so.iqiyi.com/so/q_电脑版新浪彩票分析a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=网络买彩票的平台a9840。com 复制登录 http://www.youdao.com/w/极速幸运飞艇开奖记录a9840。com 复制登录 http://so.iqiyi.com/so/q_北京赛车智能计划软件手机版a9840。com 复制登录 http://so.iqiyi.com/pps/?k=彩票ac值的作用a9840。com 复制登录 http://www.douban.com/search?q=幸运农场19码技巧a9840。com 复制登录 http://cn.engadget.com/tag/幸运飞艇交流宝典28c63。com 复制登录 http://so.iqiyi.com/so/q_北京pk10统计软件a9840。com 复制登录 http://www.xiachufang.com/search/?keyword=重庆幸运农场微信走势图a9840。com 复制登录 http://www.douban.com/search?q=7彩票今天a9840。com 复制登录 http://so.iqiyi.com/so/q_泰国彩票开奖号码最新a9840。com 复制登录 http://so.iqiyi.com/pps/?k=2019网售彩票a9840。com 复制登录